Max) of unchanged buspirone increased by 84% and 116%, respectively, but the total amount of buspirone immunoreactive material did not change. They were given a 20 mg dose with and without food the area under the plasma concentration-time curve (AUC) and peak plasma concentration (C The effects of food upon the bioavailability of buspirone hydrochloride tablets have been studied in eight subjects.
The single-dose bioavailability of unchanged buspirone when taken as a tablet is on the average about 90% of an equivalent dose of solution, but there is large variability. Peak plasma levels of 1 ng/mL to 6 ng/mL have been observed 40 to 90 minutes after single oral doses of 20 mg.
Following oral administration, plasma concentrations of unchanged buspirone are very low and variable between subjects. In a radiolabeled study, unchanged buspirone in the plasma accounted for only about 1% of the radioactivity in the plasma. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.īuspirone hydrochloride tablets are rapidly absorbed in man and undergoes extensive first-pass metabolism. In vivo when tested in preclinical models.īuspirone has moderate affinity for brain DĢ-dopamine receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HTġA) receptors. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. The mechanism of action of buspirone is unknown. Buspirone hydrochloride tablets USP contain the following inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate (Type A - potato starch).ġ Note :- Not applicable for divided doses Thus, a single tablet can provide the following doses: 30 mg (entire tablet), 20 mg (two-thirds of a tablet), 15 mg (one-half of a tablet), or 10 mg (one-third of a tablet). The 30 mg tablets are scored such that they may be bisected or trisected. Thus, a single tablet can provide the following doses: 15 mg (entire tablet), 10 mg (two-thirds of a tablet), 7.5 mg (one-half of a tablet) or 5 mg (one-third of a tablet). The 15 mg tablets are scored such that they may be bisected or trisected. Thus, the 5 mg tablet can also provide a 2.5 mg dose, and the 10-mg tablet can provide a 5 mg dose. The 5 mg, 7.5 mgġ and 10 mg tablets are scored so they can be bisected. Buspirone hydrochloride is supplied as tablets for oral administration contains 5 mg, 7.5 mg, 10 mg, 15 mg or 30 mg of buspirone hydrochloride, USP.
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